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Modified pseudomonas oleovorans phaC1 nucleic acids encoding bispecific polyhydroxyalkanoate polymerase

United States Patent

November 7, 2000
View the Complete Patent at the US Patent & Trademark Office
A genetically engineered Pseudomonas oleovorans phaC1 polyhydroxyalkanoate (PHA) polymerase having tailored substrate specificity is provided. The modified PHA polymerase is preferably a "bispecific" PHA polymerase capable of copolymerizing a short chain length monomer and a medium chain length monomer is provided. Methods for making the modified PHA polymerase and for making nucleic acids encoding the modified PHA polymerase are also disclosed, as are methods of producing PHA using the modified PHA polymerase. The invention further includes methods to assay for altered substrate specificity.
Srienc; Friedrich (Lake Elmo, MN), Jackson; John K. (Plymouth, MN), Somers; David A. (Roseville, MN)
Regents of the University of Minnesota (Minneapolis, MN)
09/ 052,689
March 31, 1998
STATEMENT OF GOVERNMENT RIGHTS This invention was made with government support under a grant from the Department of Energy (DOE) Grant No. DE FC 05920R 22072. The U.S. Government has certain rights in this invention.