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Nucleotide cleaving agents and method

United States Patent

November 7, 2000
View the Complete Patent at the US Patent & Trademark Office
The present invention provides a unique series of nucleotide cleaving agents and a method for cleaving a nucleotide sequence, whether single-stranded or double-stranded DNA or RNA, using and a cationic metal complex having at least one polydentate ligand to cleave the nucleotide sequence phosphate backbone to yield a hydroxyl end and a phosphate end.
Que, Jr.; Lawrence (Roseville, MN), Hanson; Richard S. (Falcon Heights, MN), Schnaith; Leah M. T. (Redwing, MN)
Regents of the University of Minnesota (Minneapolis, MN)
09/ 123,848
July 28, 1998
STATEMENT OF GOVERNMENT RIGHTS The present invention was made with government support from the U.S. Department of Energy (Grant DE-FG02-88ER 13862) and the National Institutes of Health (Grants GM-38767 and GM-08277). The Government has certain rights in this invention.