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Method for detecting a pericentric inversion in a chromosome

United States Patent

6,140,057
October 31, 2000
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.
Lucas; Joe N. (San Ramon, CA)
The Regents of the University of California (Oakland, CA)
09/ 304,396
May 4, 1999
The United States government has rights in this invention pursuant to Contract Number W-7405-ENG48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.