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Recombinant organisms capable of fermenting cellobiose

United States Patent

6,102,690
August 15, 2000
View the Complete Patent at the US Patent & Trademark Office
This invention relates to a recombinant microorganism which expresses pyruvate decarboxylase, alcohol dehydrogenase, Klebsiella phospho-.beta.-glucosidase and Klebsiella (phosphoenolpyruvate-dependent phosphotransferase system) cellobiose-utilizing Enzyme II, wherein said phospho-.beta.-glucosidase and said (phosphoenolpyruvate-dependent phosphotransferase) cellobiose-utilizing Enzyme II are heterologous to said microorganism and wherein said microorganism is capable of utilizing both hemicellulose and cellulose, including cellobiose, in the production of ethanol.
Ingram; Lonnie O. (Gainesville, FL), Lai; Xiaokuang (Gainesville, FL), Moniruzzaman; Mohammed (Gainesville, FL), York; Sean W. (Gainesville, FL)
Univ. of Florida Research Foundation, Inc. (Gainsville, FL)
08/ 834,901
April 7, 1997
GOVERNMENT FUNDING PARAGRAPH The invention described herein was made with government support provided, through the Florida Agricultural Experiment Station (Grant No. FLA-MCS-03445), Department of Energy, Office of Basic Energy Sciences (Grant No. DE-FG02-96ER20222) and U.S. Department of Agriculture, National Research Initiative (Grant No. 95-37308-1843). The government has certain rights in the invention.