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Method for detecting and diagnosing disease caused by pathological protein aggregation

United States Patent

6,063,636
May 16, 2000
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
A method is provided for detecting pathological macromolecules in a patient, comprising obtaining body fluid from the patient, pretreating the body fluid, subjecting the pretreated body fluid to size-exclusion chromatography to create an excluded fluid, and analyzing the excluded fluid to detect macromolecules having a predetermined molecular weight. The method also allows for comparing elution spectra with reference spectra of suspect pathologic proteins.
Stevens; Fred J. (Naperville, IL), Myatt; Elizabeth A. (Riverside, IL), Solomon; Alan (Knoxville, TN)
The United States of America as represented by the United States (Washington, DC), The University of Tennessee (Knoxville, TN)
08/ 605,294
January 19, 1996
CONTRACTUAL ORIGIN OF THE INVENTION The United States Government has rights in this invention pursuant to Contract No. W-31-109-ENG-38 between the U.S. Department of Energy and The University of Chicago representing Argonne National Laboratory.