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Process for the preparation of protected 3-amino-1,2-dihydroxypropane acetal and derivatives thereof

United States Patent

6,040,464
March 21, 2000
View the Complete Patent at the US Patent & Trademark Office
A process for producing protected 3-amino-1,2-dihydroxypropane acetal, particularly in chiral forms, for use as an intermediate in the preparation of various 3-carbon compounds which are chiral. In particular, the present invention relates to the process for preparation of 3-amino-1,2-dihydroxypropane isopropylidene acetal. The protected 3-amino-1,2-dihydroxypropane acetal is a key intermediate to the preparation of chiral 3-carbon compounds which in turn are intermediates to various pharmaceuticals.
Hollingsworth; Rawle I. (Haslett, MI), Wang; Guijun (East Lansing, MI)
Board of Trustees operating Michigan State University (East Lansing, MI)
09/ 320,989
May 27, 1999
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was supported in part by a United States Department of Energy Grant No. DE-FG02-89ER14029. The U.S. government has certain rights in this invention.