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Detection of biological molecules using boronate-based chemical amplification and optical sensors

United States Patent

6,002,954
December 14, 1999
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
Van Antwerp; William Peter (Valencia, CA), Mastrototaro; John Joseph (Los Angeles, CA), Lane; Stephen M. (Oakland, CA), Satcher, Jr.; Joe H. (Modesto, CA), Darrow; Christopher B. (Pleasanton, CA), Peyser; Thomas A. (Menlo Park, CA), Harder; Jennifer (Livermore, CA)
The Regents of the University of California (Oakland, CA), Minimed Inc. (Sylmar, CA)
08/ 749,366
November 21, 1996
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.