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DNA sequence similarity recognition by hybridization to short oligomers

United States Patent

6,001,562
December 14, 1999
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
Methods are disclosed for the comparison of nucleic acid sequences. Data is generated by hybridizing sets of oligomers with target nucleic acids. The data thus generated is manipulated simultaneously with respect to both (i) matching between oligomers and (ii) matching between oligomers and putative reference sequences available in databases. Using data compression methods to manipulate this mutual information, sequences for the target can be constructed.
Milosavljevic; Aleksandar (Westmont, IL)
The University of Chicago (Argonne, IL)
08/ 438,506
May 10, 1995
The government may own certain rights in the present invention pursuant to grants from the W-31-109-ENG-38 from the Department of Energy.