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Oncoprotein protein kinase

United States Patent

5,994,513
November 30, 1999
View the Complete Patent at the US Patent & Trademark Office
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD or 55 kD as determined by reducing SDS-PAGE, having serine and theonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
Karin; Michael (San Diego, CA), Lin; Anning (La Jolla, CA)
University of California (Oakland, CA)
09/ 150,200
September 8, 1998
This invention was made with support by Howard Hughes Medical Institute and Government support under Grant No. DE-86ER60429, awarded by the Department of Energy and Grant No. CA-50528 and CA-58396, awarded by the National Institute of Health. The Government has certain rights in this invention. Also supported by the Howard Hughes Medical Institute.