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Direct detection of x-rays for protein crystallography employing a thick, large area CCD

United States Patent

5,978,444
November 2, 1999
View the Complete Patent at the US Patent & Trademark Office
Fermi National Accelerator Laboratory - Visit the Office of Research and Technology Applications Website
An apparatus and method for directly determining the crystalline structure of a protein crystal. The crystal is irradiated by a finely collimated x-ray beam. The interaction of the x-ray beam with the crystal produces scattered x-rays. These scattered x-rays are detected by means of a large area, thick CCD which is capable of measuring a significant number of scattered x-rays which impact its surface. The CCD is capable of detecting the position of impact of the scattered x-ray on the surface of the CCD and the quantity of scattered x-rays which impact the same cell or pixel. This data is then processed in real-time and the processed data is outputted to produce a image of the structure of the crystal. If this crystal is a protein the molecular structure of the protein can be determined from the data received.
Atac; Muzaffer (Wheaton, IL), McKay; Timothy (Ann Arbor, MI)
The United States of America as represented by the United States (Washington, DC)
09/ 000,880
December 30, 1997
CONTRACTUAL ORIGIN OF THE INVENTION The United States Government has rights in this invention pursuant to Contract No. DE-AC02-76CH03000 between the U.S. Department of Energy and the University Research Association.