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Senescence responsive transcriptional element

United States Patent

5,965,543
October 12, 1999
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Recombinant polynucleotides have expression control sequences that have a senescence responsive element and a minimal promoter, and which are operatively linked to a heterologous nucleotide sequence. The molecules are useful for achieving high levels of expression of genes in senescent cells. Methods of inhibiting expression of genes in senescent cells also are provided.
Campisi; Judith (Berkeley, CA), Testori; Alessandro (Berkeley, CA)
Geron Corporation (Menlo Park, CA)
08/ 840,887
April 17, 1997
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT Certain work described herein was supported by grant no. DEA-AC03-76SF00098 between the United States Department of Energy and the University of California for the operation of Lawrence Berkeley Laboratory. The Government may have certain rights in this invention.