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Self-assembling multimeric nucleic acid constructs

United States Patent

5,965,133
October 12, 1999
View the Complete Patent at the US Patent & Trademark Office
The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to streptavidin and bound with a functional group. These constructs can be utilized in vivo to treat or identify diseased tissue or cells. Repeated administrations of multimeric nucleic acid compositions produce a rapid and specific amplification of nucleic acid constructs and their attached functional groups. For treatment purposes, functional groups may be toxins, radioisotopes, genes or enzymes. Diagnostically, labeled multimeric constructs may be used to identify specific targets in vivo or in vitro. Multimeric nucleic acids may also be used in nanotechnology and to create self-assembling polymeric aggregates such as membranes of defined porosity, microcircuits and many other products.
Cantor; Charles R. (Boston, MA), Niemeyer; Christof M. (Bremen, DE), Smith; Cassandra L. (Boston, MA), Sano; Takeshi (Boston, MA), Hnatowich; Donald J. (Brookline, MA), Rusckowski; Mary (Southborough, MA)
Trustees of Boston University (Boston, MA), Univ. of Mass. Medical Center (Worcester, MA)
08/ 967,297
November 7, 1997
RIGHTS IN THE INVENTION This invention was made with United States Government support under grant DE-FG02-93ER61656 awarded by the Department of Energy and the United States Government has certain rights in the invention.