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Method for preparing radionuclide-labeled chelating agent-ligand complexes

United States Patent

5,958,374
September 28, 1999
View the Complete Patent at the US Patent & Trademark Office
Radionuclide-labeled chelating agent-ligand complexes that are useful in medical diagnosis or therapy are prepared by reacting a radionuclide, such as .sup.90 Y or .sup.111 In, with a polyfunctional chelating agent to form a radionuclide chelate that is electrically neutral; purifying the chelate by anion exchange chromatography; and reacting the purified chelate with a targeting molecule, such as a monoclonal antibody, to form the complex.
Meares; Claude F. (Davis, CA), Li; Min (Davis, CA), DeNardo; Sally J. (El Macero, CA)
The Regents of the University of California (Oakland, CA)
08/ 767,702
December 17, 1996
REFERENCE TO GOVERNMENT SUPPORT This invention was made in part with Government support under contract number CA16861 and CA47829 awarded by the Department of Health and Human Services and contract number DE FG03-84ER60233 awarded by the Department of Energy. The Government has certain rights in this invention.