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Activated recombinant adenovirus proteinases

United States Patent

August 10, 1999
View the Complete Patent at the US Patent & Trademark Office
This application describes methods and expression constructs for producing activatable recombinant adenovirus proteinases. Purified activatable recombinant adenovirus proteinases and methods of purification are described. Activated adenovirus proteinases and methods for obtaining activated adenovirus proteinases are further included. Isolated peptide cofactors of adenovirus proteinase activity, methods of purifying and identifying said peptide cofactors are also described. Antibodies immunoreactive with adenovirus proteinases, immunospecific antibodies, and methods for preparing them are also described. Other related methods and materials are also described.
Anderson; Carl W. (Stony Brook, NY), Mangel; Walter F. (Shoreham, NY)
Associated Universities, Inc. (Washington, DC)
08/ 435,998
May 5, 1995
GOVERNMENT SUPPORT Work described herein was supported by Grant No. U01 A126049 from the National Institutes of Health and by the U.S. Department of Energy. The Government has certain rights in the invention.