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Mutation assays involving blood cells that metabolize toxic substances

United States Patent

5,935,829
August 10, 1999
View the Complete Patent at the US Patent & Trademark Office
The present invention pertains to a line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity). Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. The invention also includes mutation assays using these cells, and other cells with similar characteristics.
Crespi; Charles L. (Marblehead, MA), Thilly; William G. (Winchester, MA)
Massachusetts Institute of Technology (Cambridge, MA)
07/ 817,971
January 6, 1992
GOVERNMENT INTEREST The invention described herein was made in the course of or under grants from the U.S. Department of Energy and the National Institute for Environmental Health Sciences.