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Enhancing the sensitivity of immunoassay procedures by use of antibodies directed to the product of a reaction between probe labels and assay substrates

United States Patent

5,925,532
July 20, 1999
View the Complete Patent at the US Patent & Trademark Office
The subject invention provides an antibody which specifically binds to the product of a reaction between a labeling substance and a substrate. The subject invention also provides a method of making an immunogen used to produce the antibody of the subject invention. The invention further provides methods of using the subject antibody for detecting an antigen of interest in a sample, for example, detecting a protein comprising an amino acid sequence of interest and detecting a nucleic acid molecule comprising a nucleic acid sequence of interest, detecting a polypeptide such as those expressed by infectious agents, fungi or parasites.
Erlanger; Bernard F. (Whitestone, NY), Chen; Bi-Xing (New York, NY)
The Trustees of Columbia University in the City of New York (New York, NY)
08/ 898,583
July 22, 1997
The invention disclosed herein was made with Government support under Grant No. DE FG 02-88ER60742 from the U.S. Department of Energy. The U.S. Government has certain rights in this invention.