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Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites

United States Patent

5,919,797
July 6, 1999
View the Complete Patent at the US Patent & Trademark Office
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen isotopes by a late step synthesis that maximizes the useable lifeterm of the label. The labeled compounds are useful for localizing serotonin transporter sites by positron emission tomography and/or single photon emission computed tomography.
Goodman; Mark M. (Atlanta, GA), Faraj; Bahjat (Lithonia, GA)
Emory University (Atlanta, GA)
08/ 840,651
April 24, 1997
ACKNOWLEDGEMENT OF FEDERAL RESEARCH SUPPORT This invention was made, at least in part, with funding from the United States Department of Energy, Grant No. DE FG05-93 ER61737. Accordingly the United States Government may have certain rights in this invention.