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5'to 3' nucleic acid synthesis using 3'-photoremovable protecting group

United States Patent

5,908,926
June 1, 1999
View the Complete Patent at the US Patent & Trademark Office
The present invention relates, in general, to a method of synthesizing a nucleic acid, and, in particular, to a method of effecting 5' to 3' nucleic acid synthesis. The method can be used to prepare arrays of oligomers bound to a support via their 5' end. The invention also relates to a method of effecting mutation analysis using such arrays. The invention further relates to compounds and compositions suitable for use in such methods.
Pirrung; Michael C. (Houston, TX), Shuey; Steven W. (Durham, NC), Bradley; Jean-Claude (Durham, NC)
Duke University (Durham, NC)
08/ 406,327
March 16, 1995
This invention was made with Government support under Grant No. DEFG0592ER 61388 awarded by the Department of Energy. The Government has certain rights in the invention.