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Modified Acyl-ACP desaturase

United States Patent

5,888,790
March 30, 1999
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
Cahoon; Edgar B. (Shoreham, NY), Shanklin; John (Shoreham, NY), Lindqvist; Ylva (Jarfalla, SE), Schneider; Gunter (Jarfalla, SE)
Brookhaven Science Associates LLC (Upton, NY)
08/ 853,979
May 9, 1997
This invention was made with Government support under contract number DE-AC02-76CH00016, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.