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Targeted nucleic acid constructs and uses related thereto

United States Patent Application

20030049203
A1
View the Complete Application at the US Patent & Trademark Office
The invention provides targeted constructs comprising a targeting moiety, a nucleic acid, and a payload. The payload can be a detectable label or a therapeutic agent. The nucleic acid can be an antisense molecule that is complementary to RNA present in a target cell. The targeted constructs can be used to introduce the payload into a target cell in vivo or in vitro. Accordingly, the invention can be used for diagnostic purposes and for therapeutic purposes.
Elmaleh, David R. (Newton, MA), Fischman, Alan J. (Boston, MA), Babich, John W. (Scituate, MA)
09/ 945,166
August 31, 2001
[0001] Work described herein was supported in part by funding from the Department of Energy under DOE grant DE-FG02-86ER60460.