The invention provides methods for modulating tumor cell proliferation by contacting cells (e.g. tumor cells) with a TACE inhibitor and a compound that inhibits EGFR tyrosine kinase, whereby the TACE inhibitor enhances the sensitivity of the cell to the EGFR tyrosine kinase inhibitor. Additionally, methods for treating cancer and methods for identifying TACE inhibitors is also provided.
STATEMENT OF GOVERNMENT SUPPORT
 This invention was made with government support by Contract No. DE-AC02-05CH11231 awarded by the US Department of Energy, Office of Biological and Environmental Research, and an Innovator Award BC012005 and Contract No. DOD BCRP DAMD17-00-1-0224 awarded by the Department of Defense Breast Cancer Research Program. The government has certain rights in this invention.