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SPECTRAL BIOMARKER AND ALGORITHM FOR THE IDENTIFICATION AND DETECTION OF NEURAL STEM AND PROGENITOR CELLS AND THEIR USE IN STUDYING MAMMALIAN BRAINS

United States Patent Application

20090247860
A1
View the Complete Application at the US Patent & Trademark Office
The disclosure provides a biomarker and algorithm for identifying and detecting neural stem and progenitor cells and their use in studying mammalian brains. The disclosure further provides magnetic resonance spectroscopy methods and an image enhancing algorithm for the study of the proliferation of these cells and the associated neurogenesis in the live mammalian brain.
Djuric, Petar M. (Setauket, NY), Manganas, Louis N. (New Hide Rock, NY), Enikolopov, Grigori N. (Cold Spring Harbor, NY), Maletic-Savatic, Mirjana (Houston, TX)
RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (Albany NY), COLD SPRING HARBOR LABORATORY (Cold Spring Harbor NY)
12/ 259,177
October 27, 2008
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with government support under grant R21NS05875-1 (MMS), 5K08 NS044276 (MMS) and R01-NS32764 (GE) awarded by the National Institute of Neurological Disorders and Stroke (NINDS); grant DAMD170110754 (M.M.S.) awarded by the US Army Medical Research; grant T32DK07521-16 (L.N.M.) awarded by the National Institute of Diabetes and Digestive and Kidney Diseases; grant FWP MO-065 (H.B.) awarded by the United States Department of Energy; grant CCF-0515246 awarded by National Science Foundation; and grant N00014-06-1-0012 (P.D.) awarded by the Office of Naval Research. The government has certain rights in the invention.