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Portable Rapid Microfluidic Thermal Cycler for Extremely Fast Nucleic Acid Amplification

United States Patent Application

20090226971
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A portable apparatus for thermal cycling a material to be thermal cycled includes a portable microfluidic-compatible platform, a microfluidic heat exchanger carried by the portable microfluidic-compatible platform; a porous medium in the microfluidic heat exchanger; a microfluidic thermal cycling chamber containing the material to be thermal cycled, the microfluidic thermal cycling chamber operatively connected to the microfluidic heat exchanger; a working fluid at first temperature, a first system for transmitting the working fluid at first temperature to the microfluidic heat exchanger; a working fluid at a second temperature, a second system for transmitting the working fluid at second temperature to the microfluidic heat exchanger; a pump for flowing the working fluid at the first temperature from the first system to the microfluidic heat exchanger and through the porous medium; and flowing the working fluid at the second temperature from the second system to the heat exchanger and through the porous medium.
Beer, Neil Reginald (Pleasanton, CA), Vafai, Kambiz (Mission Viejo, CA), Mahjoob, Shadi (Riverdale, CA)
12/ 270,030
November 13, 2008
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory.