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IDENTIFICATION OF RAC1B AS A MARKER AND MEDIATOR OF METALLOPROTEINASE-INDUCED MALIGNANCY

United States Patent Application

20090191543
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides compositions and methods for detecting MMP-induced malignancies by detecting Rac1b expression. The invention further provides compositions and in vitro and in vivo methods for inhibiting MMP-induced malignant transformation by modulating Rac1b expression and/or function.
Radisky, Derek C. (Jacksonville, FL), Nelson, Celeste M. (Princeton, NJ), Bissell, Mina J. (Berkeley, CA)
THEREGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
11/ 915,726
May 26, 2006
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC03-76SF00098, now Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. This work was also supported by grants from the OBER office of the Department of Energy and an Innovator award from the Department of Defense and from the National Institutes of Health, and by fellowships from the National Cancer Institute and the Department of Defense. The government has certain rights in this invention.