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Homology Models of Mammalian Zinc Transporters and Methods of Using Same

United States Patent Application

20090171592
A1
View the Complete Application at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The present invention is a method of identifying a compound that has a sufficient level of binding with a target site on a mammalian zinc transporter, or a portion thereof. The method comprises (a) providing a homology model of a mammalian zinc transporter, or portion thereof, comprising at least one target site; and (b) employing computational means to evaluate the level of binding of the compound with the target site, or a portion thereof. If a sufficient level of binding is found, then a compound is identified.
Fu, Dax (Leonia, NJ), Lu, Min (Lake Bluff, IL)
Brookhaven Science Associates, LLC (Upton NY)
12/ 327,867
December 4, 2008
[0002] This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.