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METHODS AND SYSTEMS FOR MONITORING PRODUCTION OF A TARGET PROTEIN IN A NANOLIPOPROTEIN PARTICLE

United States Patent Application

20090136937
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Provided herein are methods and systems for the monitoring production of a target protein in of a nanolipoprotein particle (NLP) that also includes a scaffold protein and a membrane forming lipid. The target protein is capable of assuming an active form and an inactive form. Monitoring is performed by an indicator protein that is capable of assuming an active form and an inactive form, the active form associated with a detectable activity of the indicator protein, the detectable activity further associated with the active form of the target protein.
COLEMAN, Matthew A. (Oakland, CA), Hoeprich, Paul D. (Pleasanton, CA), Arroyo, Erin S. (Fairfax, CA), Cappuccio, Jenny A. (Livermore, CA)
12/ 118,530
May 9, 2008
STATEMENT OF GOVERNMENT GRANT [0002] The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the U.S. Department of Energy and Lawrence Livermore National Security, LLC, for the operation of Lawrence Livermore National Security."