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YEAST CELLS HAVING DISRUPTED PATHWAY FROM DIHYDROXYACETONE PHOSPHATE TO GLYCEROL

United States Patent Application

20090053782
A1
View the Complete Application at the US Patent & Trademark Office
Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells produce significantly less glycerol than the wild-type strains, and usually produce greater yields of desired fermentation products. Yeast cells of the invention often grow well when cultivated, despite their curtailed glycerol production.
Dundon, Catherine Asleson (Minneapolis, MN), Suominen, Pirkko (Maple Grove, MN), Aristidou, Aristos (Highland Ranch, CO), Rush, Brian J. (Minneapolis, MN), Koivuranta, Kari (Helsinki, FI), Hause, Benjamin Matthew (Currie, MN), McMullin, Thomas William (Minnetonka, MN), Roberg-Perez, Kevin (Minneapolis, MN)
12/ 281,286
March 13, 2007
[0002] This invention was made under contract no. DE-FC36-03GO13145 with the United States Department of Energy. The United States Government has certain rights to this invention.