The present invention is related generally to a method for screening subjects to determine those subjects more likely to develop diabetes by quantization of insulin producing cells. The present invention is also related to the diagnosis of diabetes and related to monitor disease progression or treatment efficacy of candidate drugs.
 This invention was made with government support under Grant Nos. DE-FG02-03ER63598, awarded by the U.S. Department of Energy. The Government has certain rights in this invention.