A method and related system for generating motion corrected tomographic images includes the steps of illuminating a region of interest (ROI) to be imaged being part of an unrestrained live subject and having at least three spaced apart optical markers thereon. At least one camera is used to obtain images of the markers. Motion data comprising 3D position and orientation of the markers relative to an initial reference position is then calculated. The at least three spaced apart optical markers and the at least one camera are sufficient in quantity and position to avoid multiple epipolar solutions. Motion corrected tomographic data obtained from the ROI using the motion data is then obtained, where motion corrected tomographic images obtained therefrom.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
 The United States Government has rights in this invention pursuant to Contract No. DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC.