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Functionalized Encoded Apoferritin Nanoparticles and Processes for Making and Using Same

United States Patent Application

20080292545
A1
View the Complete Application at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
Apoferritin nanoparticles with functionalized surfaces have been prepared that include preselected agents within the cavity of the apoferritin molecule and preselected functionalized surface characteristics on the outer surface of the nanoparticle. Such materials provide for utilization and selective modification in a variety of applications including therapeutic and diagnostic uses. Examples of several of these applications are described herein. In addition a method for the creation of these materials by alternatively assembling, functionalizing, or functionalizing, disassembling and reassemblying the materials provides for creative customization of various types of materials applicable for varying types of applications which are also described herein.
Lin, Yuehe (Richland, WA), Liu, Guodong (Fargo, ND), Wu, Hong (Richland, WA), Wang, Jun (Richland, WA), Fisher, Darrell R. (Richland, WA)
12/ 062,745
April 4, 2008
[0002] This invention was made with Government support under Contract DE-AC0676RLO-1830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.