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Method of multiplexed analysis using ion mobility spectrometer

United States Patent Application

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Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
A method for analyzing analytes from a sample introduced into a Spectrometer by generating a pseudo random sequence of a modulation bins, organizing each modulation bin as a series of submodulation bins, thereby forming an extended pseudo random sequence of submodulation bins, releasing the analytes in a series of analyte packets into a Spectrometer, thereby generating an unknown original ion signal vector, detecting the analytes at a detector, and characterizing the sample using the plurality of analyte signal subvectors. The method is advantageously applied to an Ion Mobility Spectrometer, and an Ion Mobility Spectrometer interfaced with a Time of Flight Mass Spectrometer.
Belov, Mikhail E. (Richland, WA), Smith, Richard D. (Richland, WA)
Battelle Memorial Institute
11/ 701,752
February 1, 2007
GOVERNMENT RIGHTS [0001] The invention was made with Government support under Contract DE-AC0676RLO 1830, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.