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NANOSTRUCTURE-INITIATOR MASS SPECTROMETRY

United States Patent Application

20080128608
A1
View the Complete Application at the US Patent & Trademark Office
A substrate for use in providing an ionized target comprising a structured substrate has a plurality of recesses, at least a portion of the plurality of recesses containing an initiator, the substrate being capable of having a target loaded on it. In one methods, irradiation of the substrate can cause the initiator to restructure, releasing it from the recesses and thereby desorbing and ionizing the target. The target so desorbed and ionized can be detected by mass analyzers. The mass of the targets at a given point on the surface can be recorded to provide a spatial mapping of the targets on the surface.
Northen, Trent (San Diego, CA), Siuzdak, Gary (San Diego, CA), Nordstrom, Anders (Darneryd, SE)
The Scripps Research Institute (LaJolla CA)
11/ 852,863
September 10, 2007
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] This invention was made with government support under Grants No. DE-FG02-07ER64325, awarded by the United States Department of Energy, and No. 5-P30-MHO62261-07, awarded by the United States National Institutes of Health. The government may have certain rights.