Disclosed are computational methods, and associated hardware and software products for identifying a set of target pockets for broad-spectrum drug development based on a provided set of protein motifs. A method of identifying the provided set protein motifs based on a plurality of protein motifs in also disclosed herein. Additional methods for generating a plurality of protein motifs based on both aligned protein structure and sequences are disclosed herein.
STATEMENT REGARDING FEDERALLY FUNDED RESEARCH
 The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California, for the operation of Lawrence Livermore National Laboratory.