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Fibrin carrier compound for treatment of disease

United States Patent Application

20020131935
A1
View the Complete Application at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of an [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclcide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The invention also comprises a second class of compounds, and a method of using the compounds, for treating diseases, and in particular, cancer. A fibrin carrier and a therapeutic agent, such as a radionuclide and/or chemotherapy agents, are mixed and applied to the tissue adjacent to a cancer removal site.
Fisher, Darrell R. (Richland, WA), Weller, Richard E. (Selah, WA), Lind, Michael A. (Kent, WA), Gutowska, Anna (Richland, WA), Campbell, Allison A. (Kennewick, WA)
09/ 994,509
November 26, 2001
[0002] This invention was made with Government support under Contract DE-AC06 76RLO 1830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.