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CAPTURE AND RANDOM AMPLIFICATION PROTOCOL FOR IDENTIFICATION AND MONITORING OF MICROBIAL DIVERSITY

United States Patent Application

20070264636
A1
View the Complete Application at the US Patent & Trademark Office
Sequence capture and random amplification are used to generate a population of polynucleotides that reflect the sequence diversity of a starting microbial population. The CAPRA population is used in hybridization reactions for the assessment of diversity and for the quantitation of particular members in the starting population. The polynucleotide population can also be sequenced, and/or cloned for evaluation of sequence diversity, generation of probes, generation of microarrays comprising such sequences, and the like.
CROSBY, LAUREL DIANE (Stanford, CA), CRIDDLE, CRAIG S. (Cupertino, CA)
The Board of Trustees of the Leland Stanford Junior University
11/ 381,308
May 2, 2006
[0001] This invention was made with Government support under contract DE-FG03-00ER63046, and DE-FG02-04ER3763 awarded by the Department of Energy. The Government has certain rights in this invention.