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IN VIVO ALTERATION OF CELLULAR DNA

United States Patent Application

20070243616
A1
View the Complete Application at the US Patent & Trademark Office
The present invention relates to methods, cells and compositions for performing in vivo recombination without the need for clonal selection. These methods, cells and compositions are useful for the automation of recombination. The present invention provides methods for performing sequential steps in genome engineering, as well as for achieving parallel and multiplex genome engineering.
Church, George M. (Brookline, MA), Reppas, Nikos (Brookline, MA)
President and Fellows of Harvard College (Cambridge MA)
11/ 749,489
May 16, 2007
STATEMENT OF GOVERNMENT INTERESTS [0002] This invention was made with government support under the U.S. Department of Energy GTL grant number DE-FG02-02ER63445. The Government has certain rights in the invention.