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Polymeric chelators for radionuclide delivery systems

United States Patent Application

20070224115
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A radionuclide delivery system that is based upon amorphous, water-soluble polymeric chelators. Each water-soluble polymeric chelator is capable of delivering hundreds of radionuclide atoms to the target. The chemical and physical characteristics of the globular polymer increase the effective decay-particle yield at the target cells and reduce ancillary toxicity due to errant daughter radionuclides by retaining or rebinding daughter nuclei. The delivery system includes a water-soluble polymeric chelator having a plurality of chelating groups; and a plurality of radionuclide atoms bound to a least a portion of the chelating groups, wherein the plurality of chelating groups immobilize at least a portion of the plurality of radionuclide atoms.
Barr, Mary E. (Los Alamos, NM), Atcher, Robert W. (Los Alamos, NM)
The Regents of the University of California
11/ 388,177
March 22, 2006
STATEMENT REGARDING FEDERAL RIGHTS [0001] This invention was made with government support under Contract No. W-7405-ENG-36, awarded by the U.S. Department of Energy. The government has certain rights in the invention.