A radionuclide delivery system that is based upon amorphous, water-soluble polymeric chelators. Each water-soluble polymeric chelator is capable of delivering hundreds of radionuclide atoms to the target. The chemical and physical characteristics of the globular polymer increase the effective decay-particle yield at the target cells and reduce ancillary toxicity due to errant daughter radionuclides by retaining or rebinding daughter nuclei. The delivery system includes a water-soluble polymeric chelator having a plurality of chelating groups; and a plurality of radionuclide atoms bound to a least a portion of the chelating groups, wherein the plurality of chelating groups immobilize at least a portion of the plurality of radionuclide atoms.
STATEMENT REGARDING FEDERAL RIGHTS
 This invention was made with government support under Contract No. W-7405-ENG-36, awarded by the U.S. Department of Energy. The government has certain rights in the invention.