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Sample preparation of biological cells for analysis

United States Patent Application

20070218455
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A system for reliably and reproducibly exposing the contents of a biological cell to an analysis instrument comprising a sample handling unit that includes a first substrate with first substrate face and a second substrate with second substrate face. The first substrate face and the second substrate face are opposed. The biological cell is positioned between the first substrate face and the second substrate face. A framework with a mechanism for applying a range of pressures to the first substrate face and the second substrate face reliably and reproducibly exposes the contents of the biological cell to the analysis instrument.
Knize, Mark G. (Tracy, CA), Kulp, Kristen S. (Livermore, CA), Wu, Kuang Jen J. (Cupertino, CA)
The Regents of the University of California
11/ 378,853
March 16, 2006
[0001] The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.