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Methylthioadenosine Phosphorylase Compositions and Methods of Use in the Diagnosis and Treatment of Proliferative Disorders

United States Patent Application

20070161025
A1
View the Complete Application at the US Patent & Trademark Office
Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.
Olopade, Olufunmilayo I. (Chicago, IL)
11/ 617,217
December 28, 2006
[0002] The United States government has certain rights in the present invention pursuant to Grant DE-FG02-86ER60408 from the Department of Energy, Grant CA14599-19 from the National Cancer Institute, and Grants CA40046 and CA42557 from the United States Public Health Service.