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Mass spectrometric immunoassay

United States Patent Application

20010021535
A1
View the Complete Application at the US Patent & Trademark Office
Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.
Nelson, Randall W. (Ahwahtukee, AZ), Williams, Peter (Phoenix, AZ), Krone, Jennifer Reeve (Phoenix, AZ)
09/ 808,314
March 14, 2001
[0001] The present invention relates to a new and useful immunoassay and more specifically to new and improved mass spectrometric immunoassay processes for the detection and/or quantification of one or more antigens or antibodies in a single determining immunoassay. Hereinafter, singular terms are intended to include plural. [0002] Financial Assistance for some of the work reported herein was provided by the United States Department of Energy under Grant number DEFG02-91ER61127. The United States government may have certain rights to this invention.