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Oncoprotein protein kinase

United States Patent Application

20070077581
A1
View the Complete Application at the US Patent & Trademark Office
An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and Threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of deterction of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
Karin, Michael (San Diego, CA), Hibi, Masahiko (San Diego, CA), Lin, Anning (La Jolla, CA), Davis, Roger (Princeton, MA), Derijard, Benoit (Shrewsbury, MA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
11/ 521,952
September 15, 2006
[0002] This invention was made with support by Howard Hughes Medical institute and Government support under Grant No. DE-86ER60429, awarded by the Department of Energy and Grant No. CA-50528 and CA-58396, awarded by the National Institute of Health. The Government has certain rights in this invention. Also supported by the Howard Hughes Medical Institute.