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AMPLIFICATION OF BIOLOGICAL TARGETS VIA ON-CHIP CULTURE FOR BIOSENSING

United States Patent Application

20180095083
A1
View the Complete Application at the US Patent & Trademark Office
The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
Harper, Jason C. (Rio Rancho, NM), Edwards, Thayne L. (Bend, OR), Carson, Bryan (Tijeras, NM), Finley, Melissa (Albuquerque, NM), Arndt, William (Albuquerque, NM)
15/ 820,836
November 22, 2017
STATEMENT OF GOVERNMENT INTEREST [0002] This invention was made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention.