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APOLIPOPROTEIN NANODISCS WITH TELODENDRIMER

United States Patent Application

20180079829
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a polyethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.
LUO, Juntao (Jamesville, NY), HE, Wei (Davis, CA), LAM, Kit S. (Davis, CA), HENDERSON, Paul (Dublin, CA), COLEMAN, Matthew A. (Oakland, CA)
15/ 499,855
April 27, 2017
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Grant No. R01CA115483, awarded by the National Institute of Health and Contract No. DE-AC52-07NA27344 between the U.S. Department of Energy and Lawrence Livermore National Security LLC. The Government has certain rights in this invention.