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IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY

United States Patent Application

20180028688
A1
View the Complete Application at the US Patent & Trademark Office
There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.
Waymouth, Robert M. (Palo Alto, CA), Wender, Paul (Palo Alto, CA), Vargas, Jessica R. (Palo Alto, CA), Blake, Tim R. (Palo Alto, CA), McKinlay, Colin (Palo Alto, CA), Levy, Ronald (Palo Alto, CA), Haabeth, Ole Audun Werner (Palo Alto, CA), Benner, Nancy (Palo Alto, CA), Near, Katherine (Palo Alto, CA)
15/ 662,190
July 27, 2017
STATEMENT AS TO RIGHTS TO DISCLOSURES MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under contract DE-SC0005430 awarded by the Department of Energy, under contract 1306730 awarded by the National Science Foundation and under contracts CA031841 and CA031845 awarded by the National Institutes of Health. The Government has certain rights in the invention.