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SYSTEMS AND METHODS FOR DETECTING METAL ION CONCENTRATIONS IN SUBJECTS

United States Patent Application

20180024112
A1
View the Complete Application at the US Patent & Trademark Office
A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.
Chang, Christopher J. (Berkeley, CA), Long, Jeffrey R. (Oakland, CA), Lee, Sumin (Berkeley, CA), Barin, Gokhan (Albany, CA)
15/ 593,117
May 11, 2017
STATEMENT OF GOVERNMENT RIGHTS [0002] This invention was made with government support under Grant Number GM079465 awarded by the National Institutes of Health and Grant Number DE-SC0001015 awarded by the Department of Energy. The government has certain rights in the invention.