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INCREASED ETHANOL PRODUCTION BY THERMOPHILIC MICROORGANISMS WITH DELETION OF INDIVIDUAL HFS HYDROGENASE SUBUNITS

United States Patent Application

20180023100
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A or subunit B of the hfs hydrogenase, but not deletion of subunit C or subunit D, results in an increase in ethanol yield.
Eminoglu, Aysenur (Hanover, NH), Olson, Daniel G. (Hanover, NH), Lynd, Lee R. (Plainfield, NH)
15/ 656,665
July 21, 2017
GOVERNMENT INTERESTS [0002] This invention was made with government support under Award No. DE-AC05-00OR-22725 awarded by the BioEnergy Science Center (BESC) under the Department of Energy. The government has certain rights in this invention.