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Peptides whose uptake by cells is controllable

United States Patent Application

20070041904
A1
View the Complete Application at the US Patent & Trademark Office
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
Jiang, Tao (San Diego, CA), Olsen, Emilia S. (La Jolla, CA), Whitney, Michael (San Diego, CA), Aguilera, Todd (US), Nguyen, Quyen (US), Wong, Edmund (San Diego, CA), Tsien, Roger (La Jolla, CA)
11/ 437,095
May 19, 2006
STATEMENT OF FEDERALLY-SPONSORED RESEARCH [0002] This work was supported in part by grants from the Department of Energy, DE-FG03-01ER63276 and from the National Institutes of Health Grants DK54441, GM54038 and NS27177 (NINCDS). The government may have certain rights in this invention.