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BIOPHYSICAL PLATFORM FOR DRUG DEVELOPMENT BASED ON ENERGY LANDSCAPE

United States Patent Application

20170356024
A1
View the Complete Application at the US Patent & Trademark Office
In one aspect, the present invention provides a method of selecting or identifying an agent that inhibits a target protein having an active site. In another aspect, the invention provides a method of selecting an agent that inhibits a target protein having an active site for further optimization. In some embodiments, the methods comprise measuring or predicting stability of an induced fit conformation of an agent contacted to an active site of the protein, wherein the agent is selected if the stability of the induced fit conformation of the agent contacted to the active site of the protein is increased relative to a reference stability.
KERN, DOROTHEE (WALTHAM, MA)
BRANDEIS UNIVERSITY (WALTHAM MA)
15/ 524,181
November 4, 2015
STATEMENT OF RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH [0002] This invention was made with government support under Grant No. DE-FG02-05ER15699 awarded by the U.S. Department of Energy and Grant No. GM100966-01 awarded by the National Institutes of Health. The government has certain rights in the invention.