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PREPARATION OF PLASTIC SUPPORTS FOR BIOCHIPS

United States Patent Application

20070031862
A1
View the Complete Application at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
Plastic substrates, including poly(methyl methacrylate) (PMMA) and poly(ethylene terephthalate) (PET) slides, may be modified with methods described herein and subsequently used in the manufacture or formation of biochips, or other microarrays. Illustrative methods include modifying the surface of the plastic substrates by covalent attachment of unsaturated acid derivatives that include a primary amine group for reacting with functional groups on the surface of the plastic substrate. Further illustrative methods include modifying the surface of the plastic substrates by a cleaning procedure that results in improved adhesive properties for subsequent printing. After being modified, the substrates described herein may be used to prepare 2D and 3D microarrays by printing using conventional methods.
Chernov, Boris K. (Burr Ridge, IL), Golova, Julia B. (Burr Ridge, IL), Chandler, Darrell P. (Yorkville, IL)
The University of Chicago (Chicago IL)
11/ 425,667
June 21, 2006
[0002] This invention was made in part under Contract No. W-31-109-ENG-38 between the U.S. Department of Energy and the University of Chicago representing Argonne National Laboratory. The U.S. Government may have certain rights in this invention.