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METHODS, SYSTEMS, AND COMPOSITIONS FOR STUDYING SOLVENT ACCESSIBILITY AND THREE-DIMENSIONAL STRUCTURE OF BIOLOGICAL MOLECULES

United States Patent Application

20170336390
A1
View the Complete Application at the US Patent & Trademark Office
This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.
Sussman, Michael R. (Cross Plains, WI), Shohet, J. Leon (Madison, WI), Choudhury, Faraz A. (Madison, WI), Blatz, Joshua M. (Monona, WI), Minkoff, Benjamin B. (Madison, WI), Benjamin, Daniel I. (Madison, WI)
15/ 600,352
May 19, 2017
STATEMENT REGARDING FEDERALLY FUNDED RESEARCH [0002] This invention was made with government support under MCB1410164 and CBET1066231 awarded by the National Science Foundation and DE-FG02-88ER13938 awarded by the US Department of Energy. The government has certain rights in the invention.